HOPE and TRIOS Study | Uncovering the Unknown Causes of Pregnancy Loss

Our goal with the HOPE project is to Harness multiple Opportunities for Pregnancy loss Exploration.
In the United States, millions of women get pregnant and have successful pregnancies every year.

Unfortunately, miscarriage also occurs in 8-20% of clinically recognized pregnancies. Many miscarriages can occur due to large chromosomal abnormalities. These abnormalities can be recognized and mitigated with the increasing use of preimplantation genetic testing and genetic counseling of at-risk parents. However, even with these considerations, around 50% of potentially normal embryos do not result in a clinical pregnancy.

Sponsored by the National Institute of Health, this multi-site study aims to use novel approaches to find explanations of pregnancy loss and learn how we can predict future pregnancy outcomes.

You may be eligible if you are: older than 15 years old, affected by pregnancy loss of unknown causes, and willing to donate samples for research.

Aleksander Rajkovic, MD, PhD
Principal investigator
Marina Sirota
Principal investigator
Hakan Cakmak, MD
Researcher
Eleni Jaswa, MD
Researcher
Linda Giudice
Researcher