HOPE (Harness multiple Opportunities for Pregnancy loss Exploration)
TRIOS (Trio analysis of Recurrent pregnancy loss Integrated bioinformatics genomics Study)
Recurrent pregnancy loss (RPL) can affect up to 5% of couples. Although chromosomal abnormalities explain about half of sporadic pregnancy losses, many RPL patients remain unexplained. The TRIOS Study’s aim is to understand what biological factors are associated with normal and abnormal pregnancies. Molecular profiles will examine the interactions between the genes and the environment and how metabolism and immune systems change in normal and abnormal pregnancies. This study will hopefully help providers identify possible targets and improve future treatments for families suffering with unexplained pregnancy loss.
